Two senior Justice Department officials resigned Friday: Jason Reding Quiñones, the U.S. attorney in Miami whose office oversees an investigation of President Donald Trump’s adversaries, and John Eisenberg, the head of the department’s National Security Division. Attorney General Todd Blanche announced both departures on Nov. 6.

The resignations leave the department facing leadership changes in a major federal prosecutor’s office and a division responsible for terrorism, espionage and foreign intelligence matters. They follow the departure of Civil Rights Division leader Harmeet Dhillon a day earlier. Reuters reported that the reasons for the two resignations were not clear.

The announcements came after Democrats won control of Congress in Tuesday’s midterm elections. That timing does not establish that the election caused either departure. Neither resignation, by itself, announces the closure of an investigation or a change in the department’s legal position in a pending case.

A disputed investigation loses another leader

Reding Quiñones’s office had been assigned to examine whether former intelligence and law enforcement officials engaged in a criminal effort to undermine Trump. The inquiry encompasses earlier investigations of his campaign’s contacts with Russia and his retention of classified documents after leaving office. Its central allegation remains an investigative theory, rather than a finding by a court.

ABC News reported that the so-called grand conspiracy investigation had produced no indictments and that department leaders had privately criticized Reding Quiñones over its lack of progress. Those accounts rely on sources familiar with internal discussions, rather than a public explanation from the attorney general. They provide context for his departure but do not resolve why he decided to leave.

The Associated Press reported that investigators had postponed some witnesses’ grand jury appearances and that the inquiry had already undergone personnel changes. Joseph diGenova, a former federal prosecutor brought into the investigation, left in September without bringing charges. Blanche praised Reding Quiñones’s work on crime and trafficking cases; the departing prosecutor thanked Trump and his staff.

The Miami office has a wider caseload

The leadership change affects an office with responsibilities well beyond that investigation. The Southern District of Florida prosecutes federal crimes, represents the United States in civil litigation and collects certain debts owed to the federal government. Its jurisdiction covers nine counties and more than 7 million residents, from the Florida Keys through the southeastern part of the state and inland to Sebring.

The office is headquartered in Miami, with staffed branches in Fort Lauderdale, West Palm Beach and Fort Pierce. That geographic reach makes its leadership responsible for coordinating a broad federal caseload, rather than supervising only cases with national political attention. The resignation is a change at the top of that structure, not evidence that its other prosecutions have stopped.

Reding Quiñones took office on Aug. 13, 2025, after Senate confirmation, according to his department biography. Before that appointment, he served as a Florida trial judge and worked as a federal prosecutor and national security official. His duties also included membership on the attorney general’s advisory committee and a role overseeing its white-collar and cyber-fraud work. The advisory committee provides counsel on law-enforcement policy and the operation of U.S. attorneys’ offices. His white-collar subcommittee addresses fraud, money laundering and cyber-enabled schemes, including matters that can exceed the capacity of a single district. His exit therefore removes a district leader who also participated in national discussions about prosecution priorities.

National security responsibilities also change hands

Eisenberg was confirmed and sworn in on June 5, 2025. His official profile describes a position overseeing counterterrorism, counterintelligence, export-control and national security cyber prosecutors. The role also coordinates the department’s relationship with the intelligence community and its work under the Foreign Intelligence Surveillance Act.

The division’s work extends beyond criminal trials. It handles foreign investment and telecommunications security reviews, national security policy and appellate matters, and support for Americans victimized by terrorism overseas. Its Office of Intelligence works on surveillance applications and related litigation before specialized federal courts, including oversight of how intelligence agencies implement the law. Those responsibilities explain why the leadership transition matters even where no public indictment or courtroom proceeding is imminent.

Eisenberg previously served as a National Security Council legal adviser during Trump’s first term. ABC reported that the division under his leadership was involved in the classified-information prosecution of former national security adviser John Bolton, who pleaded guilty earlier this year, as well as leak investigations involving journalists. Blanche credited Eisenberg with strengthening the government’s response to foreign and domestic threats.

What the departures establish

The resignations create a management transition; they do not establish that the underlying investigations lacked evidence or that prosecutors will abandon them. The unresolved questions include who will direct the offices and whether the department will revise the scope, staffing or timetable of the inquiry into Trump’s adversaries.

Those are separate decisions from accepting resignations. Until the department announces new leadership or takes an identifiable step in court, the confirmed change is the departure of two senior officials whose responsibilities reach across federal prosecution and national security.