Donald Trump won Indiana’s Republican primary by roughly 16 percentage points Tuesday, a decisive result that drove both remaining rivals from the race and transformed a 17-candidate contest into a one-man march toward the party’s presidential nomination.

With 59 percent of precincts reporting, Trump held 53 percent to Senator Ted Cruz’s 37 percent, while Gov. John Kasich trailed in single digits, according to contemporaneous returns compiled by CBS News. Indiana awarded 57 delegates, most on a winner-take-all basis, denying Cruz the result he needed to keep alive his plan for a contested convention.

Cruz suspended his campaign Tuesday night. Kasich followed Wednesday, leaving Trump as the only active Republican candidate and prompting Republican National Committee Chairman Reince Priebus to call him the presumptive nominee. Trump still must accumulate the formal majority of 1,237 delegates, but there is no longer an organized opponent competing against him in the remaining primaries.

The abrupt ending settles the nomination contest while opening a more difficult question: whether Trump can assemble a party whose elected leaders, donors and policy institutions have spent much of the past year resisting his candidacy.

Indiana closes Cruz’s final path

Cruz had treated Indiana as the place to halt Trump’s momentum after five losses in the Northeast. He campaigned intensively, named Carly Fiorina as a vice-presidential running mate and secured an endorsement from Gov. Mike Pence. Cruz and Kasich also announced an unusual strategy under which Kasich would give Cruz room in Indiana while Cruz would focus less on Oregon and New Mexico.

None of it produced a close contest. Trump’s margin extended across much of the state and demonstrated strength beyond the Northeast, where he had swept Pennsylvania, Maryland, Connecticut, Rhode Island and Delaware a week earlier. The result deprived Cruz of delegates and, more important, of a plausible argument that Republicans were moving toward him as the field narrowed.

“I said that I would continue on as long as there was a viable path to victory,” Cruz told supporters in Indianapolis, according to The Texas Tribune’s report from his concession. “Tonight I am sorry to say that it appears that path has foreclosed.” A full video of Cruz’s remarks showed supporters responding with dismay as he said voters had chosen another path.

Kasich had won only his home state of Ohio and remained far behind in delegates. He had argued that he was the strongest general-election candidate and hoped to prevail at a convention after multiple ballots. But Cruz’s exit removed the last substantial barrier to Trump arriving in Cleveland with a majority or close enough to obtain one.

The final rival steps away

Kasich returned to Columbus on Wednesday and ended his campaign in an emotional address. “The people of our country changed me,” he said, after thanking his family, staff and volunteers. His full withdrawal speech emphasized the encounters he had with voters rather than an endorsement of Trump.

The Ohio governor’s departure made the arithmetic straightforward. Trump can collect delegates in Nebraska, West Virginia, Oregon, Washington, California and other remaining states without sharing the field with a rival. Even before he formally reaches 1,237, the party’s apparatus must prepare for him to lead the ticket.

Priebus moved rapidly toward that conclusion Tuesday night, urging Republicans to unite and focus on defeating the Democratic nominee. The chairman’s declaration marked the institutional party’s acceptance of an outcome many officials had tried to prevent. Trump won by repeatedly presenting himself as independent of that structure, financing much of his primary effort himself and arguing that party leaders had failed voters on immigration, trade and foreign policy.

His victory speech adopted a more conciliatory tone toward Cruz than many of their final exchanges. The campaign’s closing days included highly personal accusations, underscoring the challenge of bringing Cruz’s supporters into a coalition Trump will need in November.

A nominee without a unified party

The resistance did not disappear with the competitors. House Speaker Paul Ryan, the highest-ranking elected Republican, said Thursday he was “not there yet” on supporting Trump. In a CNN interview transcript, Ryan said the nominee must demonstrate a commitment to limited government, the Constitution and conservative principles while unifying the party.

Trump answered with a parallel refusal. “I am not ready to support Speaker Ryan’s agenda,” he said in a statement discussed in CNN’s May 5 coverage, adding that the two might reach an agreement later. The exchange made clear that the post-primary negotiation will concern not just tone but who defines Republican policy.

Some Republicans have pledged to support the eventual nominee as a matter of party loyalty. Others remain opposed because of Trump’s proposed temporary ban on Muslim entry, his immigration program, his attacks on rivals and his departures from conservative positions on trade and entitlement programs. The public break with Ryan gave those divisions an institutional face.

Trump also must build a national campaign organization, expand fundraising and coordinate with a party network he frequently criticized. His primary operation has relied heavily on rallies, television exposure and a compact staff. A general-election campaign requires sustained advertising, voter data, legal operations and field offices across competitive states.

The general election begins before both primaries end

Democrats have not completed their nomination process. Senator Bernie Sanders narrowly defeated Hillary Clinton in Indiana and has vowed to continue. Clinton nevertheless holds a commanding delegate advantage and has increasingly framed her campaign against Trump.

The Republican result therefore accelerates a general-election confrontation that is not yet formally settled on either side. Trump can devote his attention to Clinton, fundraising and party unity while she continues to compete with Sanders through the final primaries.

For Republicans, Indiana delivered clarity without consensus. Voters decisively removed the possibility that convention maneuvering would substitute another candidate for Trump. They did not resolve whether the party’s governing class and its new standard-bearer can agree on a program, political language or shared organization.

The next phase will test whether the disruptive appeal that carried Trump through a crowded primary can be converted into a majority coalition. His opponents are gone. The resistance inside his party is not.